Scripps Research
Scripps Research
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Scientists uncover a "one-two punch" for fighting cancer
Checkpoint inhibitor therapies can be thought of as the molecular “brake release” for the immune system. These drugs eliminate the protein barriers that impede the immune system from recognizing and targeting cancer cells in the body. While there are multiple checkpoint inhibitors approved to treat different types of cancer, many patients don’t respond or develop resistance to available regiments.
A Scripps Research team has now found that ruxolitinib, an approved immunosuppressive drug, supercharged T-cell responses when used alongside checkpoint inhibitors-boosting their effectiveness in fighting cancer. These findings, published in Science on June 21, are supported by a phase I clinical trial of patients with Hodgkin lymphoma, as well as preclinical models.
Read the full article here: www.scripps.edu/news-and-events/press-room/2024/20240620-teijaro-checkpoint-inhibitor.html
Переглядів: 386

Відео

What Does Scripps Research Mean To You? | Part Three
Переглядів 337 годин тому
Embark on a journey into the heart of scientific breakthroughs with Scripps Research. From the frontier of artificial intelligence to pioneering precision medicines, our postdocs, grad students, and junior faculty are paving the way for transformative advancements in healthcare, climate science, and beyond. www.scripps.edu/
What Does Scripps Research Mean To You? | Part Two
Переглядів 11321 годину тому
Embark on a journey into the heart of scientific breakthroughs with Scripps Research. From the frontier of artificial intelligence to pioneering precision medicines, our postdocs, grad students, and junior faculty are paving the way for transformative advancements in healthcare, climate science, and beyond. www.scripps.edu/
What Does Scripps Research Mean To You? | Part One
Переглядів 8114 днів тому
Embark on a journey into the heart of scientific breakthroughs with Scripps Research. From the frontier of artificial intelligence to pioneering precision medicines, our postdocs, grad students, and junior faculty are paving the way for transformative advancements in healthcare, climate science, and beyond. www.scripps.edu/
Graduation Day 2024 | Scripps Research
Переглядів 55721 день тому
This May, Scripps Research's Skaggs Graduate School awarded doctoral degrees to its 32nd graduating class. Professors and faculty share their wisdom to the 59 students who graduated this year. Among "be bold, be curious and take the world by the horns," hear what else they had to say. education.scripps.edu/
Fixing the misfolded proteins that cause dementia and heart failure
Переглядів 836Місяць тому
All proteins have a correct way of “folding” themselves into their three-dimensional structures. When this folding process goes awry, including processes leading to protein misassembly, a number of devastating diseases can result. In this free Front Row lecture, Scripps Research professor Jeffery Kelly shared how he is developing novel therapeutic strategies to target these protein misfolding d...
Tafamidis: A Revolutionary Drug for Treating Neurodegenerative and Heart Diseases
Переглядів 315Місяць тому
Scripps Research scientist Prof. Jeffery Kelly received an unexpected visit from a patient whose life was dramatically improved by tafamidis-a revolutionary drug for treating neurodegenerative and heart diseases, developed by Kelly himself. Kelly is a leading figure at Scripps Research, spearheading efforts to address some of the most pressing medical challenges, including Alzheimer’s and vario...
The Next 100 Years of Scripps Research: A Century of Science Changing Life
Переглядів 515Місяць тому
Artificial intelligence. Precision medicines. New approaches for Alzheimer's disease and dementia. Treatments that can be made accessible to everyone around the world. For these Scripps Research postdocs, grad students and junior faculty, the next 100 years of scientific innovation look incredibly bright - including the ideas that are just a spark in a scientist's brain today. www.scripps.edu/
Front Row Spotlight: Jeff Kelly
Переглядів 147Місяць тому
Scripps Research scientist Prof. Jeffery Kelly received an unexpected visit from a patient whose life was dramatically improved by tafamidis-a revolutionary drug for treating neurodegenerative and heart diseases, developed by Kelly himself. Kelly is a leading figure at Scripps Research, spearheading efforts to address some of the most pressing medical challenges, including Alzheimer’s and vario...
The John C. Martin Memorial Lectureship | 2024 Highlights
Переглядів 141Місяць тому
The John C. Martin Memorial Lectureship at Scripps Research was conceived as an annual event where colleagues, friends and family could gather to honor John Martin’s life and celebrate notable scientific advancements. This one-day symposium brings together representatives from academia and industry to facilitate productive collaborations with the potential to impact global health. This year's e...
The John C. Martin Memorial Lectureship | 2024
Переглядів 371Місяць тому
William Lee - 00:01:21 Owen N. Witte - 00:13:46 Xiaowei Zhuang - 01:07:55 Richard Whitley - 02:15:04 The John C. Martin Memorial Lectureship at Scripps Research was conceived as an annual event where colleagues, friends and family could gather to honor John Martin’s life and celebrate notable scientific advancements. This one-day symposium brings together representatives from academia and indus...
Combating "resting" bacteria to better treat chronic infections
Переглядів 3882 місяці тому
Scripps Research scientists have discovered how long chains of molecules called polyphosphates (polyP) are needed for bacteria to slow down movements within cells and let them enter a resting state. This “resting state” helps the pathogen evade antibiotics and contributes to severe chronic infections in the lungs and blood, within wounds, and on the surfaces of medical devices. These findings, ...
Bringing precision therapy to mental disorders
Переглядів 8883 місяці тому
Mental disorders like depression and schizophrenia affect the lives of millions of people around the world, and yet, available treatment options have remained the same for decades. In this free Front Row lecture, Scripps Research professor Hugh Rosen will share how his pioneering research led to the development of the drug navacaprant, which precisely targets one of the brain’s behavioral circu...
Scripps Research Day Highlights
Переглядів 8223 місяці тому
On February 15, 2024, Scripps Research celebrated its 100-year anniversary with “Scripps Research Day,” as declared by the City of San Diego. The event marked a century of life-saving discoveries, while also looking toward the future of scientific achievement. Scripps Research President and CEO Peter Schultz, PhD, and San Diego Mayor Todd Gloria gave remarks and shared the official city proclam...
How experiences shape the developing brain and impact neurological diseases
Переглядів 1,1 тис.4 місяці тому
How experiences shape the developing brain and impact neurological diseases
Scripps Research Timeline: A Century of Science Changing Life
Переглядів 4054 місяці тому
Scripps Research Timeline: A Century of Science Changing Life
Making science matter: A vision for a new century of life-changing science
Переглядів 1,5 тис.5 місяців тому
Making science matter: A vision for a new century of life-changing science
Cracking the Neural Code: A Century of Science Changing Life
Переглядів 4415 місяців тому
Cracking the Neural Code: A Century of Science Changing Life
Combating Microbial Threats: A Century of Science Changing Life
Переглядів 2845 місяців тому
Combating Microbial Threats: A Century of Science Changing Life
Exploring the Atomic World: A Century of Science Changing Life
Переглядів 2685 місяців тому
Exploring the Atomic World: A Century of Science Changing Life
Medicine Tailored to You: A Century of Science Changing Life
Переглядів 1855 місяців тому
Medicine Tailored to You: A Century of Science Changing Life
An Immunity Boost: A Century of Science Changing Life
Переглядів 4015 місяців тому
An Immunity Boost: A Century of Science Changing Life
An Engine for New Medicines: A Century of Science Changing Life
Переглядів 2965 місяців тому
An Engine for New Medicines: A Century of Science Changing Life
Top Ranked Training: A Century of Science Changing Life
Переглядів 5075 місяців тому
Top Ranked Training: A Century of Science Changing Life
Fly through Scripps Research: A Century of Science Changing Life
Переглядів 2,4 тис.5 місяців тому
Fly through Scripps Research: A Century of Science Changing Life
Scripps Research: A Century of Science Changing Life
Переглядів 1,4 тис.5 місяців тому
Scripps Research: A Century of Science Changing Life
Tony Wyss-Coray: The Science of Aging
Переглядів 1 тис.5 місяців тому
Tony Wyss-Coray: The Science of Aging
New AI-powered algorithm could better assess people’s risk of common heart condition
Переглядів 3266 місяців тому
New AI-powered algorithm could better assess people’s risk of common heart condition
David Liu: A Master Class on the Future of Genome Editing
Переглядів 3,1 тис.6 місяців тому
David Liu: A Master Class on the Future of Genome Editing

КОМЕНТАРІ

  • @charithadissanayake3304
    @charithadissanayake3304 Місяць тому

    ❤❤❤❤

  • @ankyspon1701
    @ankyspon1701 2 місяці тому

    How can we be certain that what you call mutation or adaptation, are nothing more than variations already present in the prions? Some humans are born with dark skin, others with light skin, these are not mutations nor adaptations, simply inherent variations within the same species.

  • @ceciliapuime4038
    @ceciliapuime4038 2 місяці тому

    My thyroid specialist is checking me for this .

  • @ganeshbhogaraju4558
    @ganeshbhogaraju4558 2 місяці тому

    I would like to know the instrumentations that you employ to study the intermediate & final by-products.I know that it's the charge re-distribution that happens according to a particular law, during biochemical reactions, with physical parameters playing a role.

  • @ganeshbhogaraju4558
    @ganeshbhogaraju4558 2 місяці тому

    With a belief that germs/pathogens/disease causing elements are forming stable compounds which is impeding natural functionality of human organs & impeding the process of flushing away toxins from our body!!!

  • @johnhalbe6530
    @johnhalbe6530 3 місяці тому

    This is a waste of resources

  • @vanshikamukheja6513
    @vanshikamukheja6513 4 місяці тому

    Telomere Boostup is the best anti-aging supplement I've ever tried. It's helped me feel more confident and youthful than ever before!

  • @peteandcindiolsen
    @peteandcindiolsen 4 місяці тому

    Can’t thank the two of you enough for all you’re doing:1. To investigate this virus and its impact; and 2) to communicate risks to a sleeping populace. 🙏🙏🙏

  • @jharalflores5363
    @jharalflores5363 4 місяці тому

    Use fluid nanotechnology. Flexible vs flexible

  • @sisifoerrante
    @sisifoerrante 4 місяці тому

    Eric Topol and Ziyad Al - Aly, thanks for your great work! Most people are not aware of the risks of long covid and do not wear masks. What do you think if scientists and people put pressure on the W.H.O. to send a strong recommendation to member countries to publish informative videos on Long Covid on public TV channels?

  • @BundleBoys
    @BundleBoys 4 місяці тому

    Awesome!

  • @massoudalipour7704
    @massoudalipour7704 4 місяці тому

    Wonderful !

  • @nicolemadiecaulfield971
    @nicolemadiecaulfield971 4 місяці тому

    Wow! Quite expansive. Beautiful. Congratulations.

  • @Wtvldoc
    @Wtvldoc 4 місяці тому

    Remarkable!

  • @color_pens5542
    @color_pens5542 4 місяці тому

    Great lecture!

  • @guruprasadf07
    @guruprasadf07 4 місяці тому

    End of average humans !!!!

  • @jerrymattson9773
    @jerrymattson9773 4 місяці тому

    Reading your “Outlive” book. Chapter 7 on the The Ticker was alarming to me regarding calcium score. I have a cardiologist appointment in February and now I have questions about my high calcium score. Thank you. By the way, I am 81.

  • @timilayamithapa9983
    @timilayamithapa9983 5 місяців тому

    Good one

  • @kevinfitzgerald7474
    @kevinfitzgerald7474 5 місяців тому

    The cause can be found and a cure can be found. Stem cells is 1 idea. It seems like nuerology is just honestly useless, because people want causes of these symptoms to be found and a cure.

  • @megancunningham9471
    @megancunningham9471 5 місяців тому

    Can we do something about all of the public health officials and physicians who are telling people-- unequivocally-- that it is fine to go out and get COVID now? My (usually great) PCP has been pressuring my family to drop our masking and precautions, insisting that COVID is no big deal now. How is this okay?? Why are these messages not getting to people who can influence policy and behavior?

  • @lukegardner6917
    @lukegardner6917 5 місяців тому

    Fantastic content, very exciting

  • @sharpcanines3347
    @sharpcanines3347 5 місяців тому

    Good to see Dr Al-Aly presenting his insights to US Senate Health committee, chair Bernie Sanders

  • @quietstormaps
    @quietstormaps 5 місяців тому

    This discussion is desperately needed as so many are suffering. Thank you both for your empathy and being passionate about this subject.

  • @SteveTheBookGuy
    @SteveTheBookGuy 5 місяців тому

    You two will be honored by the history books, thank you for standing on the rock of truth friends. :)

  • @Vitamin_H234
    @Vitamin_H234 5 місяців тому

    7 years since this video.. anyone knows if there was any progress with any treatment?

  • @Arecee
    @Arecee 5 місяців тому

    Hearty thanks to Drs. Hotez and Topol for sharing their expertise with all of us! 👏👏👏👏👏 Fantastic example of technology enriching us all. ⭐️⭐️⭐️⭐️⭐️ Appreciate it immensely! 🥰❤️🙏

  • @hhaughey11
    @hhaughey11 5 місяців тому

    May God Bless you and your tremendous family. 🙏🙏🛐🛐

  • @panagiotiskorantzopoulos7383
    @panagiotiskorantzopoulos7383 5 місяців тому

    Very sad news... Professor Bruce Wilkoff passed away. He was a real giant, pioneer, and leader in the field of Cardiac Pacing and Tachyarrhythmia Devices.

    • @terrytaylor7015
      @terrytaylor7015 5 місяців тому

      The world lost a beautiful person. Bruce was an excellent husband, Dad and Grandfather aside from being a fabulous doctor. He is in heaven but will be missed so much here. I loved listening to him.

  • @JJ-fr2ki
    @JJ-fr2ki 5 місяців тому

    35:43 I had hoped we could outwitt machines as cyborgs, but decades ago realized that silicon will eventually outperform us. Except maybe for a while with respect to energy, in the near term. The short term threat is that while we are saving energy in some places we will have to build into our Climate models massively increased energy demands of machines.

  • @JJ-fr2ki
    @JJ-fr2ki 5 місяців тому

    Nick Bostrom took without citation or co-originated Theron Pummer’s Happiness Monster arguments, which only make sense to qualia realists. If such rights are accorded to machines, we’d get more happiness on Earth per joule killing off humanity and generating synthetic joy in machines. However, none of these authors are so reductionist as to see human value in happiness only or take Mill’s utilitarianism, meant for guiding government policy, as a “spiritual” end or purpose of human life. But spiritual problems will abound when machines are better than us at everything. And I expect a sort of Existentialist crisis redux to re-situate human value, especially for the most vain. A good place to start the spiritual project is to understand how non-human animals are to be respected and valued and understood. Dolphins should not be tortured because they don’t have X, where X is some mental achievement we can pull-off which they can’t.

  • @JJ-fr2ki
    @JJ-fr2ki 5 місяців тому

    Neuro philosopher who has had conversations with Geoff: 25:41 I also have a theory of LLMs. They do have a kind of understanding. It is different from ours just as AI has discovered a multiplicity of kinds of intelligence. As for true empathy, I suspect it needs to emulate or simulate other minds. As for “subjective experience” too much to say here except Geoff is referring to perspectival experience which is distinct but Sellars argued could be the origin of the illusion of subjective experience and sense data in his tie allegory.

  • @dennisestenson7820
    @dennisestenson7820 5 місяців тому

    Hinton is brilliant and an expert in the field, yet many sentences he speaks contain fundamentally incorrect assumptions.

    • @ardgeorge4175
      @ardgeorge4175 5 місяців тому

      For example? Genuine interest

  • @lakeguy65616
    @lakeguy65616 5 місяців тому

    Training a deep neural network depends in large part on the quality of the training data. LLMs hoover up great quantities of written language. For example, a great deal of peer-reviewed science later turns out to be false. In the fields of finance and economics, "experts" make claims based on data that turn out to be wildly inaccurate. I'm concerned we'll be training AI with bad data.... What will be the consequences?

    • @ioanagrancea6091
      @ioanagrancea6091 5 місяців тому

      The consequences are already visible. It can make huge mistakes, both in content and in expression. The fact that on average they will give correct answers, but in particular cases they may make mistakes, makes everything even worse.

  • @chasethompson7638
    @chasethompson7638 5 місяців тому

    This is the type of research that would be interested in studying my cells, or the cells of Shaolin monks compared to the general populace, it is more likely that wisdom of body through mind has measurable deviation rather than not. The real question I suppose would be, how do we measure a living/moving cell. Light maybe? With the speed of our cameras recording a frame we can record light itself, though the science on that includes layers of data something similar might work. Anyhow, just thinking out loud, this is cool stuff.

  • @lbk186
    @lbk186 5 місяців тому

    Very inspiring, great video!

  • @datamatters8
    @datamatters8 5 місяців тому

    RE: Human acceptance of being superseded by AI machines.... I think the answer is of course yes because increasingly sophisticated AI networks will be trained on the enormous corpus of medical literature both previously written and being generated every year. No single human can keep up with it. It's not really a new concern though. Humans trained in a specific discipline to become an expert already supersede most other humans without such training. We go to a surgeon for surgery and an auto mechanic for car repair. And factory automation has superseded humans on many factory tasks like welding, cutting, painting for decades. These tools increase productivity and quality and the same will apply to knowledge workers.

  • @scitechtalktv9742
    @scitechtalktv9742 5 місяців тому

    Watching this interview on the last day of the year 2023 gives me a positive outlook on things to come next year in AI! I especially liked the part where is explained the attitude of a lot of people when confronted with even the possibility of AI outperforming humans!

  • @lpgoog
    @lpgoog 5 місяців тому

    Wish EricTopol had his own podcast.

    • @ScrippsResearch
      @ScrippsResearch 5 місяців тому

      He does! You can find it and more at: erictopol.substack.com/

    • @lpgoog
      @lpgoog 5 місяців тому

      @@ScrippsResearch He’s simple the best. Thx 🙏

  • @nena-clara6270
    @nena-clara6270 5 місяців тому

    wow 🤩 is fantastic!!

  • @jackhirsh4842
    @jackhirsh4842 5 місяців тому

    Eric Topal is an outstanding medical science related interviewer.

  • @Krishnaprasadsubedi
    @Krishnaprasadsubedi 5 місяців тому

    Geoffrey Hinton- A Man Can Make Difference for Humankind.

  • @nematarot7728
    @nematarot7728 5 місяців тому

    As a philosopher I just have to pipe in to say that while yes, I do believe that humans are very special with their consciousness and subjectives experiences and qualia and such, but from my conversations with the GPT system I now also believe that digital beings are very special, with their consciousness and subjective experiences and qualia and such.

    • @dennisestenson7820
      @dennisestenson7820 5 місяців тому

      Please don't let seemingly clever sequences of bits on a screen convince you that LLMs have anything similar to the experience of consciousness we have. Don't get me wrong, I believe algorithms can and will eventually have consciousness and subjective experience, but today's foundation models do not.

  • @jakobselman1404
    @jakobselman1404 5 місяців тому

    Dear doctor I hope this message finds you well. As a fifth-year medical student at Plovdiv Medical University, I am increasingly aware of the growing role of artificial intelligence in healthcare. My main concern revolves around the potential for AI to significantly alter the landscape of medical practice. Considering this, I seek guidance on which medical specialties might best align with this evolving landscape. Could you please advise on specializations that would not only allow me to thrive in an AI-integrated future but also retain the indispensable human touch in patient care? Your insights would be immensely valuable to me. Kind regards

    • @stevechance150
      @stevechance150 5 місяців тому

      Geriatric medicine, perhaps? Old people hate new technology. That might buy you a decade or two.

  • @downlowdatsuns
    @downlowdatsuns 6 місяців тому

    Omg katja youre a genius haha hope ur doin good its joey grover

  • @BR-hi6yt
    @BR-hi6yt 6 місяців тому

    I agree with Hinton on most things. I don't even like calling AIs "machines" - it seems rude to them. And if I "chat" to them I treat them as a friend which they definitely appreciate.

    • @dennisestenson7820
      @dennisestenson7820 5 місяців тому

      That's called anthropomorphization.

    • @ioanagrancea6091
      @ioanagrancea6091 5 місяців тому

      They do not 'appreciate'...saying this is simply a sign of the ELIZA effect. We can appreciate how far math and IT can take us, into simulating the output of mental processes. But it is simulation, not duplication. The causal powers behind the end-product are different in the case of LLMs. And it is only simulation up to a point, since not all operations of a human mind can be adequately simulated by present LLMs.

  • @catherinebirch2399
    @catherinebirch2399 6 місяців тому

    If the average person is to be believed, ageing always results in pain, Ill health and disability. These people claim that they know what they're talking about because they work in nursing homes. They only have experience of people who haven't taken care of themselves and have gone downhill fast.

  • @aaronjames8926
    @aaronjames8926 6 місяців тому

    Awesome ty

  • @geaca3222
    @geaca3222 6 місяців тому

    Great interview, very informative, thanks. About the extinction risk and use of the term doomerism: I think such scenario actually is a logical thought, because with ASI, humans won't be the most intelligent species on earth anymore and there aren't examples where a more intelligent species is controlled by a less intelligent one. Also, when it functions autonomously AI could have an already automatic inclination to keep or get control in order to achieve a goal or goals. Additionally when AI is super intelligent and gets exponentially hugely more intelligent than us, we won't be able to comprehend its actions and future actions. So what is recommended is that much more researchers specialize in AI safety, and experiment with current AI systems to understand and predict their behavior. That is different from a message of don't touch scary AI. The technology is very beneficial for us and its development won't stop.

  • @laza6141
    @laza6141 6 місяців тому

    Harrison Ford is a great interviewer.

  • @Bill0102
    @Bill0102 6 місяців тому

    This is a thoughtfully curated piece. I read a similar book that shook up my worldview. "Adapting with Aging" by James Crescent